研究方向：呼吸介入技术和慢性气道疾病

代表性科研项目：

2021，嗜酸性粒细胞脱颗粒上调气道平滑肌细胞表达FGFR1促进哮喘气道重塑的机制研究,青年国自然项目

2020，基于气道内OCT成像对重症哮喘抗白介素-5受体抗体治疗后气道平滑肌表型转化的作用机制研究，广州呼吸健康研究院自主课题项目

代表性学术论文（参考文献格式）：

1. Deep Learning-Based Segmentation of Airway Morphology from Endobronchial Optical Coherence Tomography. Respiration. 2023 Jan 19;1-10.  doi: 10.1159/000528971. 3.966

2. Airway remodeling and bronchodilator responses in asthma assessed by optical coherence tomography. Allergy. 2022 Feb;77(2):646-649. doi: 10.1111/all.15062. 14.71

3. A clinical and canine experimental study in small-airway response to bronchial thermoplasty: Role of the neuronal effect. Allergol Int. 2021 Aug 13; S1323-8930(21)00087-3.  7.478

4. Hybrid stenting with silicone Y stents and metallic stents in the management of severe malignant airway stenosis and fistulas. Translational Lung Cancer Research 2021, 10(5): 2218-2228. 6.498

5. Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis. Ther Adv Respir Dis. 2021 Jan-Dec; 15: 17534666211019564. 5.158

6. Prognosis of Severe and Critical Patients Who Have Recovered from COVID-19: A Three-Month Follow-Up Respiration. 2021 Jan 21;1-4. 3.966

7. Postintubation Tracheal Stenosis Evaluated by Endobronchial Optical Coherence Tomography: A Canine Model Study. Respiration. 2020;99(6):500-507. doi: 10.1159/000506882. 3.58

8. Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. Respiration. 2019;97(1):42-51. doi: 10.1159/000492031. 3.322

9. Serum KL-6 in pulmonary alveolar proteinosis: China compared historically with Germany and Japan. J Thorac Dis. 2017 Feb;9(2):287-295.  

10. Performance evaluation of detecting circulating tumor cells and tumor cells in bronchoalveolar lavage fluid in diagnosis of peripheral lung cancer. J Thorac Dis. 2018 Apr;10(Suppl 7): S830-S837.

11. Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol . 2022 May 1;322(5): L712-L721. doi: 10.1152/ajplung.00305.2021. 6.011 

12. 全肺灌洗术治疗肺泡蛋白沉积症围手术期并发症分析.中华结核和呼吸杂志,2017,40(6):499-503.

13. 硅酮支架治疗气管支气管结核所致气道狭窄的效果分析(附17例总结).中国防痨杂志,2017,39(3):226-230.

14. 介入呼吸病学年度进展（2015-2016）.国际呼吸杂志,2016,36(18):1414-1417.

15. 局部喷洒曲安奈德联合球囊扩张治疗良性中央气道狭窄疗效研究.新医学,2016,47(11):742-746.

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