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姓 名 | 王磊 | |
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职 称 | 研究员 | |
联系方式 | leiwang2021@gzhmu.edu.cn | |
出诊时间 | ||
医疗特长 | 研究方向:粘液纤毛清除与呼吸疾病 研究工作:呼吸道粘液纤毛清除系统损伤相关的呼吸疾病,包括慢性阻塞性肺疾病、呼吸道病毒感染、原发性纤毛不动症,支气管扩张,哮喘等。研究方向:1. 疾病状态下粘液纤毛清除系统的损伤机制;2. 疾病状态下粘液纤毛清除系统与免疫系统的通讯 3. 疾病状态下粘液纤毛清除系统异常的早期诊断;4. 恢复/增强粘液纤毛清除功能的药物研发;5. 靶向呼吸道上皮的药物递送系统的开发。 |
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从医历程 | ||
科研情况 | 代表性科研项目: 1.国自然优秀青年科学基金(海外),粘液纤毛清除与慢性阻塞性肺疾病,2023-2025,主持 2.国自然面上项目,微管谷氨酸化在气道粘液纤毛清除系统维持和损伤中的功能和机制研究,2023-2026,主持 代表性学术论文(参考文献格式): 1、Wang, L.*, Paudyal, S., Kang, Y., Owa, M., Liang, F., Spektor, A. Knaut, H., Sánchez, I., and Dynlacht, B. D*. (2022). Regulators of tubulin poly-glutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly. Cell Research. PMID: 34782749.(*共同通讯作者) 2、Wang, L., Failler, M., Fu, W., and Dynlacht, B. D*. (2018). A distal centriolar protein network controls organelle maturation and asymmetry. Nature Communications. PMID: 30258116. 3、Wang, L.*, and Dynlacht, B. D. *(2018). The regulation of cilium assembly and disassembly in development and disease. Development. PMID: 30224385.(*共同通讯作者) 4、Wang, L.#, Lee, K.#, Malonis, R., Sanchez, I., and Dynlacht, B. D*. (2016). Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. eLife. PMID: 27146717. 5、Wang, L#., Fu, C.#, Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A*., Jing Q. *, Liu T. *, and Zhou Y*. (2013). miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development. PMID: 23698347. 6、Wang, L.#, Zhang, Y.#, Zhou, T., Fu, Y. F., Du, T. T., Jin, Y., Chen, Y., Ren, C. G., Peng, X. L., Deng, M., and Liu, T*. (2008). Functional characterization of lmo2-Cre transgenic zebrafish. Developmental dynamics. PMID: 18627109. 获奖及个人荣誉: 1、DOD Prostate Cancer Research Program, Postdoctoral Training Award, USA, 2016-2018 |
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学术任职 |